24.10.2017: Richard STRASSER (Wien): Plant protein glycosylation: from mechanisms to applications, HS 31.11, Institut für Pflanzenwissenschaften, Bereich Pflanzenwissenschaften, Schubertstraße 51, 17:00 Uhr.
Protein glycosylation is an essential co- and post-translational modification of secretory and membrane proteins in all eukaryotes. The initial steps of N-glycosylation and N-glycan processing are highly conserved between plants, mammals and yeast. In contrast, late N-glycan maturation steps in the Golgi differ significantly in plants giving rise to complex N-glycans. While the essential role of N-glycan modifications on distinct mammalian glycoproteins is already well documented, we have only begun to decipher the biological function of this ubiquitous protein modification in different plant species. In this seminar, I will summarize our recent efforts towards a better understanding of protein glycosylation in plants and highlight approaches to engineer these pathways in order to produce recombinant glycoproteins for therapeutic use in humans.